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Abstract Background Oral semaglutide is a novel glucagon-like peptide-1 (GLP-1) analog that has been associated with improvements in glycated hemoglobin (HbA1c) and body weight versus sodium-glucose cotransporter-2 inhibitor empagliflozin and injectable GLP-1 receptor agonist dulaglutide in the PIONEER 2 clinical trial and in a recent network meta-analysis (NMA), respectively

This limitation may also explain the lack of significant, measurable changes in key metabolites such as TRP, KYNA, and LKYN, which are critical components of the kynurenine pathway

A fiber supplement may help if dietary adjustments are not enough

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